In vitro and in vivo biological performance of Mg-based bone implants

Andreea Mariana Negrescu, Madalina-Georgiana Necula, Marieta Costache, Anisoara Cimpean

https://10.31178/rbbs.2020.3.1.2.   Published online: 17 July 2020

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With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.


Keywords Magnesium, alloys, biodegradable bone implants, surface coatings, bone regeneration


Corresponding author: Anisoara Cimpean, E-mail:

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