Role of genital tract infections and inflammatory processes in male infertility

Codruța Silea, Alina Maria Holban, Mariana Carmen Chifiriuc      Published online: 25 June 2018

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Abstract Inflammation and male genital tract infections could interfere with the spermatogenesis process and lead to damages in sperm quality, as well as to seminal tract obstruction, being thus considered two of the most important causes of male infertility. Therefore, currently, there is an acute need for a better standardization of the methodology used in the clinical practice to detect and identify microorganisms infecting the male urogenital tract and also for the correct diagnosis of inflammatory processes correlated with male infertility. This paper aims to review some of the physiological changes of the main determinants of sperm quality induced by inflammatory and infectious processes, such as increased seminal leucocytes, oxidative stress and cytokines production.


Keywords male infertility; infection; inflammation


Corresponding author: Alina Maria Holban, E-mail: